ARN24139 | Topoisomerase II inhibitor | Probechem Biochemicals

Chemical Structure : ARN24139

ARN24139 (ARN-24139)

Catalog No.: PC-28061Not For Human Use, Lab Use Only.

ARN24139 (ARN-24139) is a potent topoisomerase II (Topo II) inhibitor with IC50 of 7.3 uM, shows high cytotoxicity in cancer cell lines (DU145, HeLa, A549) with IC50 of 3.1-4.7 uM.

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Biological Activity

ARN24139 (ARN-24139) is a potent topoisomerase II (Topo II) inhibitor with IC50 of 7.3 uM, shows high cytotoxicity in cancer cell lines (DU145, HeLa, A549) with IC50 of 3.1-4.7 uM.

Physicochemical Properties

M.Wt	499.46
Formula	C24H16F3N3O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Pyrimidinecarboxamide, hexahydro-4,6-dioxo-1,3-diphenyl-2-thioxo-N-[3-(trifluoromethoxy)phenyl]-

References

1. Arencibia JM, et al. J Med Chem. 2020 Apr 9;63(7):3508-3521.

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ARN24139 (ARN-24139)

Biological Activity

Physicochemical Properties

References

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