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Chemical Structure : ARN24928
Catalog No.: PC-22521Not For Human Use, Lab Use Only.
ARN24928 is a potent, selective inhibitor of CDC42 GTPases (CDC42, RHOJ, RHOQ), exhibits s antiproliferative activity of melanoma cancer cell lines that have a BRAFV600E mutation (SKM28, SKMel3, WM3248, A375) with IC50 of 3.2-6.9 uM.
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ARN24928 is a potent, selective inhibitor of CDC42 GTPases (CDC42, RHOJ, RHOQ), exhibits s antiproliferative activity of melanoma cancer cell lines that have a BRAFV600E mutation (SKM28, SKMel3, WM3248, A375) with IC50 of 3.2-6.9 uM.
ARN24928 (10 mg/kg) significantly inhibits tumor growth in the PDX model.
| M.Wt | 374.49 | |
| Formula | C22H26N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Brindani N, et al. J Med Chem. 2023 Apr 27;66(8):5981-6001.
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