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ARN24928

Chemical Structure : ARN24928

CAS No.: 3036492-84-6

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ARN24928 (ARN-24928)

Catalog No.: PC-22521Not For Human Use, Lab Use Only.

ARN24928 is a potent, selective inhibitor of CDC42 GTPases (CDC42, RHOJ, RHOQ), exhibits s antiproliferative activity of melanoma cancer cell lines that have a BRAFV600E mutation (SKM28, SKMel3, WM3248, A375) with IC50 of 3.2-6.9 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ARN24928 is a potent, selective inhibitor of CDC42 GTPases (CDC42, RHOJ, RHOQ), exhibits s antiproliferative activity of melanoma cancer cell lines that have a BRAFV600E mutation (SKM28, SKMel3, WM3248, A375) with IC50 of 3.2-6.9 uM.
    ARN24928 (10 mg/kg) significantly inhibits tumor growth in the PDX model.

    Physicochemical Properties

    M.Wt 374.49
    Formula C22H26N6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N1,N1-dimethyl-N3-(4-phenyl-6-(piperidin-4-yl)-1,3,5-triazin-2-yl)benzene-1,3-diamine

    References

    1. Brindani N, et al. J Med Chem. 2023 Apr 27;66(8):5981-6001.

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