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Chemical Structure : ARN25499
Catalog No.: PC-22520Not For Human Use, Lab Use Only.
ARN25499 is a potent, selective inhibitor of CDC42 GTPases (CDC42, RHOJ, RHOQ), exhibits s antiproliferative activity of melanoma cancer cell lines that have a BRAFV600E mutation (SKM28, SKMel3, WM3248, A375) with IC50 of 8-13.5 uM.
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ARN25499 is a potent, selective inhibitor of CDC42 GTPases (CDC42, RHOJ, RHOQ), exhibits s antiproliferative activity of melanoma cancer cell lines that have a BRAFV600E mutation (SKM28, SKMel3, WM3248, A375) with IC50 of 8-13.5 uM.
ARN25499 shows improved in vitro metabolic stability compared to ARN22089 and ARN25062.
ARN25499 (10 mg/kg, injected via tail vein) slows the growth of melanoma PDX tumors in NSG mice.
| M.Wt | 390.49 | |
| Formula | C23H26N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Brindani N, et al. J Med Chem. 2024 Jun 12. doi: 10.1021/acs.jmedchem.4c00855.
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