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ARN3261

Chemical Structure : ARN3261

CAS No.: 1613711-28-6

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ARN3261 (GRN-300, ARN-3261)

Catalog No.: PC-61952Not For Human Use, Lab Use Only.

ARN3261 (GRN-300, ARN-3261) is a potent, selective, orally available salt inducible kinase SIK2 and SIK3 inhibitor with IC50 of 11 nM and 19 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ARN3261 (GRN-300, ARN-3261) is a potent, selective, orally available salt inducible kinase SIK2 and SIK3 inhibitor with IC50 of 11 nM and 19 nM, respectively.
    ARN3261 specifically inhibits SIK2-expressed SKOv3 cells with IC50 of 92 nM; demonstrates effectivity against ovarian, breast cancer cell lines alone and in combination with Paclitaxel and Cisplatin.
    ARN3261 also inhibits ovarian tumor growth significantly in SKOv3 human ovarian cancer xenografts in mice.

    Physicochemical Properties

    M.Wt 486.54
    Formula C24H24F2N4O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(3,5-difluoro-2-methoxyphenyl)-5-(1-(1-(methylsulfonyl)piperidin-4-yl)-1H-pyrazol-4-yl)-1H-indole

    References

    1. Patent US20140256704 A1.

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