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ART26.12

Chemical Structure : ART26.12

CAS No.: 2766800-24-0

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ART26.12 (ART 26.12)

Catalog No.: PC-21691Not For Human Use, Lab Use Only.

ART26.12 is a third generation, selective fatty acid-binding protein 5 (FABP5) inhibitor with Ki value of 0.77 uM, >25-fold selective over FABP3, FABP4 and FABP7.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ART26.12 is a third generation, selective fatty acid-binding protein 5 (FABP5) inhibitor with Ki value of 0.77 uM, >25-fold selective over FABP3, FABP4 and FABP7.
ART26.12 is effective at treating and preventing oxaliplatin-induced neuropathy.
Coadministration of ART26.12 (10 and 25 mg/kg BID for 15 days) with oxaliplatin prevented thermal hyperalgesia, mitigated mechanical allodynia, and attenuated OXA-induced weight loss in oxaliplatin-induced peripheral neuropathy (OIPN) model.

Physicochemical Properties

M.Wt 472.54
Formula C29H28O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

(+)-3-Indan-2-yloxycarbonyl-2,4-bis(2-methoxyphenyl)cyclobutanecarboxylic acid

References

1. W G Warren, et al. J Pain. 2024 Jan 15:S1526-5900(24)00345-6.

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