Chemical Structure : ARV-771
CAS No.:
1949837-12-0
ARV-771
(ARV 771, ARV771)
Catalog No. : PC-42297Not For Human Use, Lab Use Only.
ARV-771 (ARV771) is a potent BET degrader (PROTAC), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4229701
Biological Activity
ARV-771 (ARV771) is a potent BET degrader (PROTAC ), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM.
Physicochemical Properties
M.Wt
986.6398
Formula
C49H60ClN9O7S2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(2S,4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-c
References
1. Raina K, et al. Proc Natl Acad Sci U S A.
2. Saenz DT, et al. Leukemia.
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