AS-136A | MeV RdRp inhibitor | Probechem Biochemicals

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Chemical Structure : AS-136A

AS-136A (AS-136a, AS136A)

Catalog No.: PC-26062Not For Human Use, Lab Use Only.

AS-136A is a potent, non nucleoside inhibitor of measles virus (MeV) virus RNA-dependent RNA polymerase (RdRp) activity with EC50 of 12 nM against live MeV (strain Alaska) in virus titer reduction assays.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	402.39
Formula	C16H17F3N4O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-methyl-N-(4-(pyrrolidin-1-ylsulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

References

1. Yoon JJ, et al. Antimicrob Agents Chemother. 2009 Sep;53(9):3860-70.

2. Ndungu JM, et al. J Med Chem. 2012 May 10;55(9):4220-30.

3. Aiming Sun, et al. Bioorg Med Chem Lett. 2007 Sep 15;17(18):5199-203.

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AS-136A (AS-136a, AS136A)

Biological Activity

Physicochemical Properties

References

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