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Chemical Structure : AS-1763
CAS No.: 2227211-00-7
Catalog No.: PC-72757Not For Human Use, Lab Use Only.
Milrebrutinib (AS1763, AS-1763) is a potent, selective, noncovalent, and orally available inhibitor of BTK with IC50 of 0.85 nM and 0.99 nM for wild-type BTK and C481S mutant, respectively.
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Milrebrutinib (AS1763, AS-1763) is a potent, selective, noncovalent, and orally available inhibitor of BTK with IC50 of 0.85 nM and 0.99 nM for wild-type BTK and C481S mutant, respectively.
AS-1763 is a next-generation noncovalent BTK inhibitor with significant efficacies in vivo tumor xenograft models.
| M.Wt | 578.648 | |
| Formula | C33H31FN6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(3-(2-amino-6-(1-(oxetan-3-yl)-1,2,3,6-tetrahydropyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2-(hydroxymethyl)phenyl)-6-cyclopropyl-8-fluoroisoquinolin-1(2H)-one |
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1. Wataru Kawahata, et al. J. Med. Chem. 2021, 64, 19, 14129–14141.
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