AS-605240 (AS605240) is a potent, selective, ATP-competitive, orally active PI3Kγ inhibitor with IC50 of 8 nM.
AS-605240 displays 30-fold selectivity for PI3Kδ、β, 7.5-fold selectivity over PI3Kα.
AS-605240 inhibits C5a-mediated PKB phosphorylation in RAW264 mouse macrophages (IC50=90 nM).
AS-605240 reduces neutrophil chemotaxis in vivo and suppresses joint inflammation and damage in mouse models of RA.
