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Chemical Structure : AS105
CAS No.: 1026029-18-4
Catalog No.: PC-72972Not For Human Use, Lab Use Only.
AS105 (AS-105) is a highly potent, ATP-competitive CaMKII inhibitor, inhibits CaMKIIδ with IC50 of 8 nM, Ki of 3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $228 | In stock | |
| 5 mg | $388 | In stock | |
| 10 mg | $588 | In stock | |
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AS105 (AS-105) is a highly potent, ATP-competitive CaMKII inhibitor, inhibits CaMKIIδ with IC50 of 8 nM, Ki of 3 nM.
AS105 is also effective against autophosphorylated CaMKII (in contrast to the commonly used allosteric CaMKII-inhibitor KN-93).
In isolated atrial cardiomyocytes from human donors and ventricular myocytes from CaMKIIδC-overexpressing mice with heart failure, AS105 effectively reduced diastolic SR Ca2+ leak by 38% to 65% as measured by Ca2+-sparks or tetracaine-sensitive shift in [Ca2+]i.
AS105 effectively reduced SR Ca2+-leak, thus improving SR Ca2+-accumulation and reducing cellular arrhythmogenic correlates, without negatively influencing excitation-contraction coupling.
| M.Wt | 339.827 | |
| Formula | C18H18ClN5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO (3.4 mg/mL) |
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| Chemical Name/SMILES |
N1-(3-(2-((3-chlorophenyl)amino)pyrimidin-4-yl)phenyl)ethane-1,2-diamine |
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1. Stefan Neef, et al. J Mol Cell Cardiol. 2018 Feb;115:73-81.
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