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Chemical Structure : AS1907417
Catalog No.: PC-20440Not For Human Use, Lab Use Only.
AS1907417 is a potent, selective GPR119 agonist with cAMP EC50 of 1.1 uM (human GPR119).
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AS1907417 is a potent, selective GPR119 agonist with cAMP EC50 of 1.1 uM (human GPR119).
AS1907417 is inactive towards several other GPCRs, including the b-adrenergic and GLP-1 receptors.
AS1907417 (0.1 to 10 uM) resulted in a concentration-dependent increase in GSIS at high glucose levels (22.4 mM) in mouse pancreatic β-cell line MIN6-B1, induces human insulin promoter activity.
A single dose of AS1907417 improved glucose tolerance, but did not affect plasma glucose or insulin levels.
AS1907417 improved plasma glucose, plasma insulin, pancreatic insulin content, lipid profiles, and increased pancreatic insulin and pancreatic and duodenal homeobox 1 (PDX-1) mRNA levels in db/db mice.
| M.Wt | 393.50 | |
| Formula | C19H27N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shigeru Yoshida, et al. Biochem Biophys Res Commun. 2010 Oct 1;400(4):745-51.
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