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AS2030680

Chemical Structure : AS2030680

CAS No.: 2170562-35-1

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AS2030680 (AS 2030680)

Catalog No.: PC-49161Not For Human Use, Lab Use Only.

AS2030680 is a potent, selective and brain-penetrating 5-HT5A receptor antagonist with Ki of 0.58, 1.1 and 2.6 nM against human, rat, mouse 5-HT5A receptors, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AS2030680 is a potent, selective and brain-penetrating 5-HT5A receptor antagonist with Ki of 0.58, 1.1 and 2.6 nM against human, rat, mouse 5-HT5A receptors, respectively.
    AS2030680 displays 15-fold greater selectivity for 5-HT5A over 5-HT1A, 5-HT2B, and 5-HT7 receptors, and no significant affinity for 5-HT2A/3/4 receptors.
    AS2030680 (0.01-0.03 mg/kg, p.o.) ameliorated scopolamine-induced working memory deficit in mice and improved reference memory impairment in aged rats.

    Physicochemical Properties

    M.Wt 428.209
    Formula C17H13BrF3N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(diaminomethylene)-4-(2,4,6-trifluorophenyl)-2H-chromene-6-carboxamide hydrobromide

    References

    1. Yamazaki M, et al. J Pharmacol Sci. 2015 Mar;127(3):362-9.

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