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AS2674723

Chemical Structure : AS2674723

CAS No.: 1392819-23-6

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AS2674723 (AS 2674723, AS-2674723)

Catalog No.: PC-49159Not For Human Use, Lab Use Only.

AS2674723 is a potent, selective and brain-penetrating 5-HT5A receptor antagonist with Ki of 0.75, 0.67 and 1.9 nM against human, rat, mouse 5-HT5A receptors, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AS2674723 is a potent, selective and brain-penetrating 5-HT5A receptor antagonist with Ki of 0.75, 0.67 and 1.9 nM against human, rat, mouse 5-HT5A receptors, respectively.
    AS2674723 displays 10-fold greater selectivity for 5-HT5A over 5-HT7 receptor, and no significant affinity for 5-HT2A/2B/2C/3/4/6 receptors.
    AS2674723 (0.01-0.03 mg/kg, p.o.) ameliorated scopolamine-induced working memory deficit in mice and improved reference memory impairment in aged rats.

    Physicochemical Properties

    M.Wt 482.392
    Formula C21H18F4N4O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(diaminomethylene)-5-fluoro-8-(2,4,6-trifluorophenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide fumarate

    References

    1. Yamazaki M, et al. J Pharmacol Sci. 2015 Mar;127(3):362-9.

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