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AS2676293

Chemical Structure : AS2676293

CAS No.: 1393999-79-5

AS2676293 (AS 2676293)

Catalog No.: PC-21026Not For Human Use, Lab Use Only.

AS2676293 (AS 2676293) is an orally active small-molecule receptor activator of nuclear factor-κB ligand (RANKL) inhibitor, inhibits RANKL-induced osteoclastogenesis using RAW264 cells with IC50 of 0.19 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AS2676293 (AS 2676293) is an orally active small-molecule receptor activator of nuclear factor-κB ligand (RANKL) inhibitor, inhibits RANKL-induced osteoclastogenesis using RAW264 cells with IC50 of 0.19 uM.
    AS2676293 (0.3-3 mg/kg, oral) inhibited bone loss significantly in RANKL-induced osteopenic mice.
    AS2676293 markedly inhibited bone metastasis of human breast cancer cells MDA-MB-231-5a-D-Luc2 as well as tumour-induced osteolysis.
    AS2676293 suppressed RANKL-mediated tumour migration in the transwell assay and inhibited bone metastasis of the murine cell line B16F10, which is known not to trigger osteoclast activation.

    Physicochemical Properties

    M.Wt 378.33
    Formula C18H14F4N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(4-fluoro-2-(trifluoromethyl)benzyl)-5-methoxy-2-(pyridin-2-yl)pyrimidin-4-amine

    References

    1. Junji Miyata, et al. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5681-4.

    2. Vagelis Rinotas, et al. Int J Mol Sci. 2023 Jul 10;24(14):11290.

    3. Nakai Y, et al. Bone Res. 2019 Jan 3;7:1. doi: 10.1038/s41413-018-0036-5.

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