Chemical Structure : AS2676293
CAS No.:
1393999-79-5
AS2676293
(AS 2676293)
Catalog No.: PC-21026Not For Human Use, Lab Use Only.
AS2676293 (AS 2676293) is an orally active small-molecule receptor activator of nuclear factor-κB ligand (RANKL) inhibitor, inhibits RANKL-induced osteoclastogenesis using RAW264 cells with IC50 of 0.19 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AS2676293 (AS 2676293) is an orally active small-molecule receptor activator of nuclear factor-κB ligand (RANKL) inhibitor, inhibits RANKL-induced osteoclastogenesis using RAW264 cells with IC50 of 0.19 uM.
AS2676293 (0.3-3 mg/kg, oral) inhibited bone loss significantly in RANKL-induced osteopenic mice.
AS2676293 markedly inhibited bone metastasis of human breast cancer cells MDA-MB-231-5a-D-Luc2 as well as tumour-induced osteolysis.
AS2676293 suppressed RANKL-mediated tumour migration in the transwell assay and inhibited bone metastasis of the murine cell line B16F10, which is known not to trigger osteoclast activation.
Physicochemical Properties
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M.Wt
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378.33
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Formula
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C18H14F4N4O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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COC1=CN=C(C2=NC=CC=C2)N=C1NCC3=CC=C(F)C=C3C(F)(F)F
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References
1. Junji Miyata, et al. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5681-4.
2. Vagelis Rinotas, et al. Int J Mol Sci. 2023 Jul 10;24(14):11290.
3. Nakai Y, et al. Bone Res. 2019 Jan 3;7:1. doi: 10.1038/s41413-018-0036-5.
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