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Chemical Structure : AS604872
Catalog No.: PC-20528Not For Human Use, Lab Use Only.
AS604872 is a potent and selective prostaglandin F2α receptor (FP) antagonist with a Ki of 35 nM, 158 nM and 323 nM for human, rat and mouse FP receptors, respectively.
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AS604872 is a potent and selective prostaglandin F2α receptor (FP) antagonist with a Ki of 35 nM, 158 nM and 323 nM for human, rat and mouse FP receptors, respectively.
AS604872 inhibited spontaneous uterine contractions in pregnant rat near term.
AS604872 delayed parturition induced by either the antiprogesterone RU-486 or the endotoxin lipopolysaccharide.
Combination of AS604872 and ritodrine showed an additive inhibitory effect on spontaneous uterine contractions in rat.
| M.Wt | 515.65 | |
| Formula | C28H25N3O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rocco Cirillo, et al. Am J Obstet Gynecol. 2007 Jul;197(1):54.e1-9.
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