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AS604872

Chemical Structure : AS604872

CAS No.: 612532-48-6

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AS604872 (AS 604872)

Catalog No.: PC-20528Not For Human Use, Lab Use Only.

AS604872 is a potent and selective prostaglandin F2α receptor (FP) antagonist with a Ki of 35 nM, 158 nM and 323 nM for human, rat and mouse FP receptors, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AS604872 is a potent and selective prostaglandin F2α receptor (FP) antagonist with a Ki of 35 nM, 158 nM and 323 nM for human, rat and mouse FP receptors, respectively.
AS604872 inhibited spontaneous uterine contractions in pregnant rat near term.
AS604872 delayed parturition induced by either the antiprogesterone RU-486 or the endotoxin lipopolysaccharide.
Combination of AS604872 and ritodrine showed an additive inhibitory effect on spontaneous uterine contractions in rat.

Physicochemical Properties

M.Wt 515.65
Formula C28H25N3O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C([C@@H]1SCCN1S(=O)(C2=CC=C(C3=CC=CC=C3)C=C2)=O)N[C@H](C4=CC=CC=C4)C5=NC=CC=C5

References

1. Rocco Cirillo, et al. Am J Obstet Gynecol. 2007 Jul;197(1):54.e1-9.

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