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Chemical Structure : ASB 14780
Catalog No.: PC-60713Not For Human Use, Lab Use Only.
ASB 14780 (ASB14780, ASB-14780) is a potent, selective and orally active cytosolic phospholipase A2α (cPLA2α) inhibitor with IC50 of 20 nM.
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ASB 14780 (ASB14780, ASB-14780) is a potent, selective and orally active cytosolic phospholipase A2α (cPLA2α) inhibitor with IC50 of 20 nM.
ASB 14780 displays excellen selectivity over other known secreted phospholipase A2s (sPLA2s), such as sPLA2-IA, sPLA2-IIA, sPLA2-III, and sPLA2-IB.
ASB 14780 markedly ameliorates liver injury and hepatic fibrosis, attenuates the CCl4-induced expression of α-SMA protein and the mRNA expression of collagen 1a2, α-SMA, and TGF-β1 in the liver, and inhibits the expression of monocyte/macrophage markers, CD11b and MCP-1 in vivo, while preventing the recruitment of monocytes/macrophages to the liver.
| M.Wt | 582.69 | |
| Formula | C31H27NO3 · C4H11NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tomoo T, et al. J Med Chem. 2014 Sep 11;57(17):7244-62.
2. Kanai S, et al. J Pharmacol Exp Ther. 2016 Mar;356(3):604-14.
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