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ASK1-IN-19

Chemical Structure : ASK1-IN-19

CAS No.: 2089638-10-6

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ASK1-IN-19 (ASK1 inhibitor 19)

Catalog No.: PC-60150Not For Human Use, Lab Use Only.

AKS1-IN-19 is a novel potent, selective and orally active ASK1 (MAP3K5) inhibitor with pIC50 of 8.3.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AKS1-IN-19 is a novel potent, selective and orally active ASK1 (MAP3K5) inhibitor with pIC50 of 8.3.
    AKS1-IN-19 displays good kinase selectivity with only 32 kinases having less than 30 fold selectivity in a panel of 356 kinases.
    AKS1-IN-19 inhibits phospho-JNK with pEC50 of 8.2 in cellular assays.
    AKS1-IN-19 displayed robust MAP3K pathway inhibition and reduction of infarct size in an isolated perfused heart model of cardiac injury.

    Physicochemical Properties

    M.Wt 393.447
    Formula C21H23N5O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-2-(6-(4-(1-hydroxypropan-2-yl)-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-6-isopropoxyisoindolin-1-one

    References

    1. Lanier M, et al. ACS Med Chem Lett. 2017 Feb 8;8(3):316-320.

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