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Chemical Structure : ASK1-IN-19
Catalog No.: PC-60150Not For Human Use, Lab Use Only.
AKS1-IN-19 is a novel potent, selective and orally active ASK1 (MAP3K5) inhibitor with pIC50 of 8.3.
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AKS1-IN-19 is a novel potent, selective and orally active ASK1 (MAP3K5) inhibitor with pIC50 of 8.3.
AKS1-IN-19 displays good kinase selectivity with only 32 kinases having less than 30 fold selectivity in a panel of 356 kinases.
AKS1-IN-19 inhibits phospho-JNK with pEC50 of 8.2 in cellular assays.
AKS1-IN-19 displayed robust MAP3K pathway inhibition and reduction of infarct size in an isolated perfused heart model of cardiac injury.
| M.Wt | 393.447 | |
| Formula | C21H23N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lanier M, et al. ACS Med Chem Lett. 2017 Feb 8;8(3):316-320.
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