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Chemical Structure : ASK1 inhibitor 32
Catalog No.: PC-38656Not For Human Use, Lab Use Only.
ASK1 inhibitor 32 is a potent, selective and brain penetrant ASK1 inhibitor with cellular IC50 of 25 nM.
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ASK1 inhibitor 32 is a potent, selective and brain penetrant ASK1 (MAP3K) inhibitor with cellular IC50 of 25 nM.
ASK1 inhibitor 32 inhibited ASK1 in the central nervous system (CNS) was evaluated in a human tau transgenic (Tg4510) mouse model exhibiting elevated brain inflammation.
ASK1 inhibitor 32 (3, 10, and 30 mg/kg, BID/PO for 4 days) showed a robust reduction of inflammatory markers (e.g., IL-1β) in the cortex.
| M.Wt | 410.333 | |
| Formula | C17H14F4N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. J Howard Jones, et al. J Med Chem. 2021 Oct 28;64(20):15402-15419.
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