ASK1 inhibitor 32

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Chemical Structure : ASK1 inhibitor 32

Catalog No.: PC-38656Not For Human Use, Lab Use Only.

ASK1 inhibitor 32 is a potent, selective and brain penetrant ASK1 inhibitor with cellular IC50 of 25 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ASK1 inhibitor 32 is a potent, selective and brain penetrant ASK1 (MAP3K) inhibitor with cellular IC50 of 25 nM.
ASK1 inhibitor 32 inhibited ASK1 in the central nervous system (CNS) was evaluated in a human tau transgenic (Tg4510) mouse model exhibiting elevated brain inflammation.
ASK1 inhibitor 32 (3, 10, and 30 mg/kg, BID/PO for 4 days) showed a robust reduction of inflammatory markers (e.g., IL-1β) in the cortex.

Physicochemical Properties

M.Wt	410.333
Formula	C17H14F4N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5-fluoro-2-methoxy-N-(6-(4-(1,1,1-trifluoropropan-2-yl)-4H-1,2,4-triazol-3-yl)pyridin-2-yl)nicotinamide

References

1. J Howard Jones, et al. J Med Chem. 2021 Oct 28;64(20):15402-15419.

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