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Chemical Structure : ASP-6537
Catalog No.: PC-60430Not For Human Use, Lab Use Only.
ASP-6537 (FK 881, FR 122047) is a novel potent, selective, reversible cyclooxygenase-1 (COX-1) inhibitor with IC50 of 4.9 nM.
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ASP-6537 (FK 881, FR 122047) is a novel potent, selective, reversible cyclooxygenase-1 (COX-1) inhibitor with IC50 of 4.9 nM.
ASP-6537 displays 650-fold selectivity over COX-2 (IC50=3.2 uM).
ASP-6537 dose dependently inhibits carrageenan-induced paw edema (ED30=22 mg/kg) and paw swelling associated with adjuvant arthritis (ED50=17 mg/kg) in rats.
ASP-6537 also inhibits TXA2 production more selectively than aspirin in in vitro and in vivo, exerts potent antithrombotic effect in rats.
| M.Wt | 311.341 | |
| Formula | C17H17N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Imanishi J, et al. Biochem Pharmacol. 2011 Oct 1;82(7):746-54.
2. Sakata C, et al. Thromb Res. 2013 Jul;132(1):56-62.
3. Sakata C, et al. Eur J Pharmacol. 2017 Mar 5;798:72-76.
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