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Chemical Structure : ASP1617
Catalog No.: PC-22165Not For Human Use, Lab Use Only.
ASP1617 (ASP-1617) is a potent, highly specific and orally active cathepsin S (CatS) inhibitor with IC50 of 4.6 nM and 0.39 nM for human and mouse CatS, respectively.
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ASP1617 (ASP-1617) is a potent, highly specific and orally active cathepsin S (CatS) inhibitor with IC50 of 4.6 nM and 0.39 nM for human and mouse CatS, respectively.
ASP1617 does not show significant activity for CatB, CatV, matriptase 2, and papain activities on a panel 61 different proteases.
ASP1617 induced invariant chain accumulation and decreased the expression level of MHC class ΙΙ on the cell surface in both mouse and human B cells.
ASP1617 prevented DO11.10 mice T cell proliferation to ovalbumin antigen.
Oral administration of ASP1617 suppressed anti-dsDNA IgG, prevented progression of lupus-like glomerulonephritis, and significantly prevented proteinuria excretion in SLE mouse model.
| M.Wt | 567.59 | |
| Formula | C28H34F5N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yuka Kawato, et al. Eur J Pharmacol. 2022 Mar 15:919:174826.
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