Chemical Structure : ASP1617
CAS No.:
2241184-85-8
ASP1617
(ASP-1617)
Catalog No.: PC-22165Not For Human Use, Lab Use Only.
ASP1617 (ASP-1617) is a potent, highly specific and orally active cathepsin S (CatS) inhibitor with IC50 of 4.6 nM and 0.39 nM for human and mouse CatS, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ASP1617 (ASP-1617) is a potent, highly specific and orally active cathepsin S (CatS) inhibitor with IC50 of 4.6 nM and 0.39 nM for human and mouse CatS, respectively.
ASP1617 does not show significant activity for CatB, CatV, matriptase 2, and papain activities on a panel 61 different proteases.
ASP1617 induced invariant chain accumulation and decreased the expression level of MHC class ΙΙ on the cell surface in both mouse and human B cells.
ASP1617 prevented DO11.10 mice T cell proliferation to ovalbumin antigen.
Oral administration of ASP1617 suppressed anti-dsDNA IgG, prevented progression of lupus-like glomerulonephritis, and significantly prevented proteinuria excretion in SLE mouse model.
Physicochemical Properties
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M.Wt
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567.59
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Formula
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C28H34F5N5O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2S,4R)-N-(1-Cyanocyclopropyl)-4-[difluoro[4-[(4-methyl-1-piperazinyl)methyl]-2-(trifluoromethyl)phenyl]methyl]-1-[(1-methylcyclopropyl)carbonyl]-2-pyrrolidinecarboxamide
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References
1. Yuka Kawato, et al. Eur J Pharmacol. 2022 Mar 15:919:174826.
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