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ASP2535

Chemical Structure : ASP2535

CAS No.: 374886-51-8

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ASP2535 (ASP 2535, ASP-2535)

Catalog No.: PC-61002Not For Human Use, Lab Use Only.

A potent, selective, brain permeable, orally available glycine transporter-1 (GlyT1) inhibitor with IC50 of 92 nM (rat GlyT1), 50-fold selectivity over GlyT2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ASP2535 is a potent, selective, brain permeable, orally available glycine transporter-1 (GlyT1) inhibitor with IC50 of 92 nM (rat GlyT1), 50-fold selectivity over GlyT2.
    ASP2535 shows minimal affinity for many other receptors except for μ-opioid receptors (IC50=1.83 uM).
    ASP2535 inhibits ex vivo [(3)H]-glycine uptake in mouse cortical homogenate, improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease.

    Physicochemical Properties

    M.Wt 382.427
    Formula C22H18N6O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole

    References

    1. Harada K, et al. Eur J Pharmacol. 2012 Jun 15;685(1-3):59-69.

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