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Chemical Structure : ASP2535
Catalog No.: PC-61002Not For Human Use, Lab Use Only.
A potent, selective, brain permeable, orally available glycine transporter-1 (GlyT1) inhibitor with IC50 of 92 nM (rat GlyT1), 50-fold selectivity over GlyT2.
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A potent, selective, brain permeable, orally available glycine transporter-1 (GlyT1) inhibitor with IC50 of 92 nM (rat GlyT1), 50-fold selectivity over GlyT2; shows minimal affinity for many other receptors except for μ-opioid receptors (IC50=1.83 uM); inhibits ex vivo [(3)H]-glycine uptake in mouse cortical homogenate, improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease.
Schizophrenia
Phase 1 Discontinued
| M.Wt | 382.427 | |
| Formula | C22H18N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Harada K, et al. Eur J Pharmacol. 2012 Jun 15;685(1-3):59-69.
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