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Chemical Structure : ASP3026
CAS No.: 1097917-15-1
Catalog No.: PC-43495Not For Human Use, Lab Use Only.
ASP3026 is a potent small molecule ALK inhibitor with IC50 of 3.5, 10, 5.4 and 6.8 nM for wt ALK, ALK F1174L, ALK R1275Q and NPM1-ALK, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $168 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ASP3026 is a potent small molecule ALK inhibitor with IC50 of 3.5, 10, 5.4 and 6.8 nM for wt ALK, ALK F1174L, ALK R1275Q and NPM1-ALK, respectively.
ASP3026 also potently inhibits Ack, EGFR L858R, FRK and LTK with IC50 of 5-85 nM, inhibits the growth of NCI-H2228 cells with IC50 of 64.8 nM.
ASP3026 enhances the antitumor activities of paclitaxel and pemetrexed without affecting body weight in mice model.
| M.Wt | 580.74 | |
| Formula | C29H40N8O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1,3,5-Triazine-2,4-diamine, N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]- |
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1. Mori M, et al. Mol Cancer Ther. 2014 Feb;13(2):329-40.
2. George SK, et al. Oncotarget. 2014 Jul 30;5(14):5750-63.
3. Mologni L, et al. Oncotarget. 2015 Mar 20;6(8):5720-34.
4. Iikubo K, et al. Chem Pharm Bull (Tokyo). 2018;66(3):251-262.
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