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ASP8302

Chemical Structure : ASP8302

CAS No.: 1839583-42-4

ASP8302 (ASP-8302, ASP 8302)

Catalog No.: PC-72280Not For Human Use, Lab Use Only.

ASP8302 (ASP 8302) is a potent, selective, positive allosteric modulator (PAM) of muscarinic M3 receptor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ASP8302 (ASP 8302) is a potent, selective, positive allosteric modulator (PAM) of muscarinic M3 receptor.
    Threonine 230 (Thr 230) is the amino acid essential for the PAM effect of ASP8302.

    Physicochemical Properties

    M.Wt 590.158
    Formula C26H32ClN7O3S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3-[(2S)-4-(5-{[4-(4-chlorothiophen-2-yl)-5-{[(2R)-2-methylpyrrolidin-1-yl]methyl}-1,3-thiazol-2-yl]carbamoyl}pyrazin-2-yl)-2-methylpiperazin-1-yl]propanoic acid

    References

    1. Okimoto R, et al. J Pharmacol Exp Ther. 2021 Oct;379(1):64-73.

    2. Okimoto R, et al. Low Urin Tract Symptoms. 2022 Feb 12.

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