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ASP9436

Chemical Structure : ASP9436

CAS No.: 1401807-89-3

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ASP9436 (ASP-9436;ASP 9436)

Catalog No.: PC-60996Not For Human Use, Lab Use Only.

ASP9436 (ASP-9436) is a potent, selective brain penetrant and orally active phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 8.0 nM, >420-fold selectivity over other PDE subtypes.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ASP9436 (ASP-9436) is a potent, selective, brain penetrant and orally active phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 8.0 nM, >420-fold selectivity over other PDE subtypes.
    ASP9436 attenuates locomotor activity with ED50 of 7.0 mg/kg, and improves visual-recognition memory deficit in animal model for the positive symptoms of schizophrenia.

    Physicochemical Properties

    M.Wt 498.408
    Formula C25H25Cl2N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-methyl-5-(1-methyl-3-{[4-(1-methyl-1H-benzimidazol-4-yl)phenoxy]methyl}-1H-pyrazol-4-yl)pyridin-2(1H)-one dihydrochloride

    References

    1. Hamaguchi W, et al. Bioorg Med Chem. 2015 Jul 1;23(13):3351-67.

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