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Chemical Structure : ASP9436
Catalog No.: PC-60996Not For Human Use, Lab Use Only.
ASP9436 (ASP-9436) is a potent, selective brain penetrant and orally active phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 8.0 nM, >420-fold selectivity over other PDE subtypes.
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ASP9436 (ASP-9436) is a potent, selective, brain penetrant and orally active phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 8.0 nM, >420-fold selectivity over other PDE subtypes.
ASP9436 attenuates locomotor activity with ED50 of 7.0 mg/kg, and improves visual-recognition memory deficit in animal model for the positive symptoms of schizophrenia.
| M.Wt | 498.408 | |
| Formula | C25H25Cl2N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hamaguchi W, et al. Bioorg Med Chem. 2015 Jul 1;23(13):3351-67.
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