Catalog No.: PC-60993Not For Human Use, Lab Use Only.
ASP9853 is a potent, orally active iNOS inhibitor (IC50=10 nM, NO release DLD-1 cells) that prevents dimerization of iNOS, but has no effect on the expression or enzyme activity of iNOS.
ASP9853 is a potent, orally active iNOS inhibitor (IC50=10 nM, NO release DLD-1 cells) that prevents dimerization of iNOS, but has no effect on the expression or enzyme activity of iNOS.
ASP9853 reduces NOx production in plasma from rats exposed to LPS (IC50=1.6 mg/kg), without effect on mean arterial blood pressure.
ASP9853 also shows greater tumor growth inhibition than docetaxel alone against non-small lung cancer xenografts in combination with docetaxe.
