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Chemical Structure : ASR490
Catalog No.: PC-38195Not For Human Use, Lab Use Only.
ASR490 (ASR 490) is a small molecule that binds to NRR of Notch1, specifically inhibits Notch1-mediated survival of colorectal cancer cells (IC50=0.6-1.2 uM).
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ASR490 (ASR 490) is a small molecule that binds to NRR of Notch1, specifically inhibits Notch1-mediated survival of colorectal cancer cells (IC50=0.6-1.2 uM).
ASR490 overcomes Notch1 overexpression and inhibits the growth of HCT/Notch1 transfectants, reduces Notch1-mediated tumor burden in xenografts.
| M.Wt | 575.702 | |
| Formula | C34H41NO7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ashish Tyagi, et al. Mol Cancer Ther. 2020 Dec;19(12):2422-2431.
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