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Chemical Structure : ASS234
Catalog No.: PC-35409Not For Human Use, Lab Use Only.
ASS234 (ASS-234) is a multitarget, potent, and CNS permeable inhibitor with IC50 of 5.2, 43, 350 and 460 nM for MAO-1, MAO-B, EeAChE and eqBuChE, respectively.
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ASS234 (ASS-234) is a multitarget, potent, and CNS permeable inhibitor with IC50 of 5.2, 43, 350 and 460 nM for MAO-1, MAO-B, EeAChE and eqBuChE, respectively.
ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro.
ASS234 completely blocks the aggregation mediated by AChE of both Aβ1-42 and Aβ1-40, showing a dual binding site to AChE.
ASS234 significantly reduces Aβ1-42-mediated toxicity in SH-SY5Y human neuroblastoma cells, ASS234 is a promising multitarget drug candidates with potential impact for Alzheimer's disease.
| M.Wt | 443.635 | |
| Formula | C29H37N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bolea I, et al. J Med Chem. 2011 Dec 22;54(24):8251-70.
2. Bolea I, et al. Curr Alzheimer Res. 2013 Oct;10(8):797-808.
3. del Pino J, et al. CNS Neurosci Ther. 2014 Jun;20(6):568-70.
4. Marco-Contelles J, et al. Front Neurosci. 2016 Jun 28;10:294.
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