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AT-090

Chemical Structure : AT-090

CAS No.: 2099681-59-9

AT-090 (AT090, AT 090)

Catalog No.: PC-61549Not For Human Use, Lab Use Only.

AT-090 is a potent, selective nociceptin/orphanin FQ receptor (NOP receptor) agonist with Ki of 5.61 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AT-090 is a potent, selective nociceptin/orphanin FQ receptor (NOP receptor) agonist with Ki of 5.61 nM.
    AT-090 displays >15-fold selectivity over mu, and >40-fold over kappa opioid receptors.
    AT-090 induces concentration dependent contractions of the mouse colon tissues with potency and efficacy similar to N/OFQ.
    AT-090 is a useful pharmacological tool for investigating the therapeutic potential of NOP partial agonists.

    Physicochemical Properties

    M.Wt 354.494
    Formula C22H30N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-(1-((1s,4s)-4-iso-propylcyclohexyl)piperidin-4-yl)indoline-2,3-dione

    References

    1. Ferrari F, et al. Eur J Pharmacol. 2016 Dec 15;793:1-13.

    2. Asth L, et al. Neuropharmacology. 2016 Jun;105:434-442.

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