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AT-101

Chemical Structure : AT-101

CAS No.: 866541-93-7

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AT-101 ((R)-(-)-Gossypol acetic acid;(-)-Gossypol acetic acid)

Catalog No.: PC-44439Not For Human Use, Lab Use Only.

AT-101 ((R)-(-)-Gossypol acetic acid) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AT-101 ((R)-(-)-Gossypol acetic acid)  is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes.
AT-101 a BH3 mimetic that binds and antagonizes anti-apoptotic effect of Bcl-2 family proteins, inhibits tumor growth in Wus1-bearing mice.

Physicochemical Properties

M.Wt 578.6064
Formula C32H34O10
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO; Methanol: 7.75 mg/mL
Chemical Name/SMILES

[2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2R)-, compd. with acetic acid (1:1)

References

1. Lin J, et al. Oncol Rep. 2013 Aug;30(2):731-8.

2. Ciereszko A, et al. Aquat Toxicol. 2000,49(3):181-187.

3. Ferdek PE, et al. Cell Death Dis. 2017 Mar 2;8(3):e2640.

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