Chemical Structure : AT-121 hydrochloride
CAS No.:
2099681-71-5
AT-121 hydrochloride
Catalog No.: PC-27540Not For Human Use, Lab Use Only.
AT-121 hydrochloride (AT121) is a potent, selective bifunctional nociceptin/orphanin FQ peptide / Mu opioid peptide (NOP/MOP) receptor agonist with Ki of 3.67/16.49 nM, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AT-121 hydrochloride (AT121) is a potent, selective bifunctional nociceptin/orphanin FQ peptide / Mu opioid peptide (NOP/MOP) receptor agonist with Ki of 3.67/16.49 nM, respectively.
AT-121 showshigh potency (EC50=35 nM) and partial agonist efficacy at the NOP receptor relative to N/OFQ, and high potency (EC50=20 nM) and partial agonist activity at the MOP receptor, relative to DAMGO.
AT-121 shows significantly lower binding affinity at the DOP or KOP receptors (Ki >100 nM).
AT-121 (0.003-0.03 mg/kg, s.c. injection) produces potent antinociceptive and antiallodynic effects in nonhuman primates and humans.
AT-121 does not induce side effects commonly associated with opioids, such as respiratory depression, abuse potential, opioid-induced hyperalgesia, and physical dependence.
Physicochemical Properties
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M.Wt
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499.11
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Formula
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C24H39ClN4O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Sulfamide, N-[2-[1,2-dihydro-1'-[cis-4-(1-methylethyl)cyclohexyl]-3-oxospiro[isoquinoline-4(3H),4'-piperidin]-2-yl]ethyl]- hydrochloride
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References
1. Ding H, et al. Sci Transl Med. 2018 Aug 29;10(456):eaar3483.
2. Elawy BE, et al. PLoS One. 2026 Apr 20;21(4):e0347529.
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