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Chemical Structure : AT-127
Catalog No.: PC-61550Not For Human Use, Lab Use Only.
AT-127 is a novel potent, selective nociceptin/orphanin FQ receptor (NOP receptor) agonist with Ki of 1.18 nM.
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AT-127 is a novel potent, selective nociceptin/orphanin FQ receptor (NOP receptor) agonist with Ki of 1.18 nM; displays >60-fold selectivity over mu and kappa opioid receptors; induces concentration dependent contractions of the mouse colon tissues with potency and efficacy similar to N/OFQ; a useful pharmacological tool for investigating the therapeutic potential of NOP partial agonists.
| M.Wt | 369.509 | |
| Formula | C22H31N3O2 | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Ferrari F, et al. Eur J Pharmacol. 2016 Dec 15;793:1-13.
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