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AT-127

Chemical Structure : AT-127

CAS No.: 2099680-72-3

AT-127 (AT 127, AT127)

Catalog No.: PC-61550Not For Human Use, Lab Use Only.

AT-127 is a potent, selective nociceptin/orphanin FQ receptor (NOP receptor) agonist with Ki of 1.18 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AT-127 is a potent, selective nociceptin/orphanin FQ receptor (NOP receptor) agonist with Ki of 1.18 nM.
    AT-127 displays >60-fold selectivity over mu and kappa opioid receptors.
    AT-127 induces concentration dependent contractions of the mouse colon tissues with potency and efficacy similar to N/OFQ
    AT-127 is a useful pharmacological tool for investigating the therapeutic potential of NOP partial agonists.

    Physicochemical Properties

    M.Wt 369.509
    Formula C22H31N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (Z)-3-(hydroxyimino)-1-(1-((1s,4s)-4-isopropylcyclohexyl)piperidin-4-yl)indolin-2-one

    References

    1. Ferrari F, et al. Eur J Pharmacol. 2016 Dec 15;793:1-13.

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