AT-130 |CAS:211364-06-6 Probechem Biochemicals

Chemical Structure : AT-130

CAS No.: 211364-06-6

AT-130 (AT130)

Catalog No.: PC-63327Not For Human Use, Lab Use Only.

AT-130 is a potent inhibitor of HBV capsid assembly, inhibits wild-type HBV replication with IC50 of 2.4 uM.

Packing	Price	Stock
5 mg	$178	In stock
10 mg	$288	In stock
25 mg	$478	In stock
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

AT-130 is a potent inhibitor of HBV capsid assembly, inhibits wild-type HBV replication with IC50 of 2.4 uM.
AT-130 inhibits replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro with same sensitivity (rtL180M, rtM204I, and rtL180M + rtM204V); blocks HBV replication at the level of viral RNA packaging, interferes with capsid morphogenesis.
AT-130 shows activity against the main lamivudine- and adefovir-resistant mutants.

Physicochemical Properties

M.Wt	488.338
Formula	C22H22BrN3O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(1-bromo-1-(2-methoxyphenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)-4-nitrobenzamide

References

1. Delaney WE 4th, et al. Antimicrob Agents Chemother. 2002 Sep;46(9):3057-60.

2. Feld JJ, et al. Antiviral Res. 2007 Nov;76(2):168-77.

3. Billioud G, et al. Antiviral Res. 2011 Nov;92(2):271-6.

AT-130 (AT130)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.