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AT-527

Chemical Structure : AT-527

CAS No.: 2241337-84-6

AT-527 (AT527, Bemnifosbuvir hemisulfate, RG-6422)

Catalog No.: PC-72626Not For Human Use, Lab Use Only.

AT-527 (AT527, Bemnifosbuvir hemisulfate, RG-6422) is a novel phosphoramidate prodrug of AT-511 that has potent in vitro activity against HCV (EC50=5-28 nM), also inhibits replication of SARS-CoV-2 with EC90 of 0.47 uM.

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Biological Activity

AT-527 (AT527, Bemnifosbuvir hemisulfate, RG-6422) is a novel phosphoramidate prodrug of AT-511 that has potent in vitro activity against HCV (EC50=5-28 nM), also inhibits replication of SARS-CoV-2 with EC90 of 0.47 uM.
AT-527 shows similar potency against human coronavirus (HCoV)-229E, HCoV-OC43, and SARS-CoV in Huh-7 cells, with little to no cytotoxicity was observed for AT-511 at concentrations up to 100 uM.
Once in cells, AT-527 is converted into its triphosphate form, AT-9010, that presumably targets the viral RNA-dependent RNA polymerase (RdRp, nsp12), for incorporation into viral RNA.
AT-9010 outcompetes all native nucleotides for NiRAN binding, inhibiting its nucleotidyltransferase activity.

Physicochemical Properties

M.Wt 1261.1563
Formula C48H68F2N14O18P2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

100 mM in DMSO (126.1 mg/mL)

Chemical Name/SMILES

isopropyl ((S)-(((2R,3R,4R,5R)-5-(2-amino-6-(methylamino)-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate hemisulfate

References

1. Good SS, et al. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e02479-20.

2. Do TND, et al. Antiviral Res. 2021 Aug;192:105122.

3. Wang X, et al. bioRxiv. 2021 Jul 21:2021.07.21.453274.

4. Good SS, et al. PLoS One. 2020 Jan 8;15(1):e0227104.

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