ATG12-ATG3 inhibitor 189 (Compound 189) is a selective inhibitor of autophagy targeting ATG12-ATG3 protein-protein interaction with IC50 of 9.3 uM.
ATG12-ATG3 inhibitor 189 (Compound 189) reduces the levels of lipidated LC3B (LC3B-II) relative to the unlipidated form (LC3B-I) upon induction of autophagosomes with torin1 and CQ.
ATG12-ATG3 inhibitor 189 (Compound 189) (5 uM) reduces autophagy levels and the growth of autophagy-addicted pancreatic PANC1 and NCI-H460 cell lines.
ATG12-ATG3 inhibitor 189 (Compound 189) displays a selective inhibitory effect on the growth of autophagy addicted tumor cells and inhibited secretion of IL1B/IL-1β (interleukin 1 beta) by macrophage-like cells.
