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Chemical Structure : ATG12-ATG3 inhibitor 189
CAS No.: 333351-38-5
Catalog No.: PC-20824Not For Human Use, Lab Use Only.
ATG12-ATG3 inhibitor 189 (Compound 189) is a selective inhibitor of autophagy targeting ATG12-ATG3 protein-protein interaction with IC50 of 9.3 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $478 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ATG12-ATG3 inhibitor 189 (Compound 189) is a selective inhibitor of autophagy targeting ATG12-ATG3 protein-protein interaction with IC50 of 9.3 uM.
ATG12-ATG3 inhibitor 189 (Compound 189) reduces the levels of lipidated LC3B (LC3B-II) relative to the unlipidated form (LC3B-I) upon induction of autophagosomes with torin1 and CQ.
ATG12-ATG3 inhibitor 189 (Compound 189) (5 uM) reduces autophagy levels and the growth of autophagy-addicted pancreatic PANC1 and NCI-H460 cell lines.
ATG12-ATG3 inhibitor 189 (Compound 189) displays a selective inhibitory effect on the growth of autophagy addicted tumor cells and inhibited secretion of IL1B/IL-1β (interleukin 1 beta) by macrophage-like cells.
| M.Wt | 327.40 | |
| Formula | C18H17NO3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(4-hydroxynaphthalen-1-yl)-2,4-dimethylbenzenesulfonamide |
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1. Gal Chaim Nuta, et al. Autophagy. 2023 Feb 22;1-14.
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