ATG4B inhibitor a25

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Chemical Structure : ATG4B inhibitor a25

Catalog No.: PC-27272Not For Human Use, Lab Use Only.

ATG4B inhibitor a25 is a small-molecule inhibitor of ATG4B with binding KD of 18.01 nM, modulates autophagy in esophageal squamous cell carcinoma (ESCC).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ATG4B inhibitor a25 is a small-molecule inhibitor of ATG4B with binding KD of 18.01 nM, modulates autophagy in esophageal squamous cell carcinoma (ESCC).
ATG4B inhibitor a25 effectively blocks autophagic flux, decreasesLC3-II levels and increased p62 accumulation.
ATG4B inhibitor a25 inhibits the proliferation of ESCC cells with IC50 of 5 uM.
ATG4B inhibitor a25 suppresses ESCC tumor growth in vivo with no obvious toxicity.

Physicochemical Properties

M.Wt	587.66
Formula	C30H32F3N3O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	butyl 3-(((4-sulfamoylphenethyl)amino)methyl)-1-(4-(trifluoromethyl)benzyl)-1H-indole-2-carboxylate

References

1. Wenke Jin, et al. Bioorg Chem. 2026 Jun 28:180:110185.

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