Chemical Structure : ATH-1105
CAS No.:
3060541-19-4
ATH-1105
(Brelgometon, ATH1105)
Catalog No.: PC-27412Not For Human Use, Lab Use Only.
Brelgometon (ATH-1105) is a small-molecule, CNS-penetrant positive modulator of hepatocyte growth factor (HGF) signaling system, augments phosphorylation of MET, ERK, and AKT in vitro.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Brelgometon (ATH-1105) is a small-molecule, CNS-penetrant positive modulator of hepatocyte growth factor (HGF) signaling system, augments phosphorylation of MET, ERK, and AKT in vitro.
ATH-1105 attenuated glutamate-mediated excitotoxicity in primary motor neurons and motor neuron- astrocyte cocultures, and had protective effects on motor neurons and neuromuscular junctions in motor neuron-muscle cocultures.
ATH-1105 mitigated LPS-induced inflammation in microglia- and macrophage-like cell systems.
ATH-1105 treatment resulted in improved motor and nerve function, sciatic nerve axon and myelin integrity, and survival in Amyotrophic lateral sclerosis (ALS) mice.
ATH-1105 reduced the levels of plasma biomarkers of inflammation and neurodegeneration, along with decreased pathological protein accumulation (phospho-TDP-43) in the sciatic nerve.
Physicochemical Properties
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M.Wt
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411.47
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Formula
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C21H28F3N3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2H-Pyrazino[1,2-a]pyrimidine-4,7(3H,6H)-dione, tetrahydro-6-methyl-8-[(2S)-2-methylbutyl]-1-[[4-(trifluoromethyl)phenyl]methyl]-, (6S)-
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References
1. Berthiaume AA, et al. Front Neurosci. 2024 Feb 8;18:1348157.
2. Berthiaume AA, et al. Front Neurol. 2026 Jan 8;16:1582765.
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