Chemical Structure : ATI-2307
CAS No.:
873546-31-7
ATI-2307
(T-2307)
Catalog No.: PC-21197Not For Human Use, Lab Use Only.
ATI-2307 (T-2307) is a pentamidine-like compound with antifungal activity, selectively targets fungal mitochondria via a fungal-specific transporter that is not present in mammalian cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ATI-2307 (T-2307) is a pentamidine-like compound with antifungal activity, selectively targets fungal mitochondria via a fungal-specific transporter that is not present in mammalian cells.
ATI-2307 shows a broad spectrum of activity against many fungal pathogens including Candida spp, Aspergillus spp., and C. neoformans.
ATI-2307 shows IC50 of 0.01-0.06 ug/mL against C. neoformans clinical isolates from Uganda.
ATI-2307 demonstrates significant fungicidal activity at dosages between 1 and 2 mg/kg/d, and is superior to fluconazole and similar to amphotericin B treatment in rabbit model cryptococcal meningoencephalitis (CM).
ATI-2307 disrupts the mitochondrial membrane potential and inhibits the respiratory chain complexes of fungi-it thus represents a new mechanism for direct antifungal action.
Physicochemical Properties
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M.Wt
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437.59
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Formula
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C25H35N5O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-{3-[1-(3-{4-[amino(imino)-methyl]phenoxy}propyl)piperidin-4-yl]propoxy}benzamidine
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References
1. Gerlach ES, et al. Front Cell Infect Microbiol. 2021 Jun 23;11:695240.
2. Giamberardino CD, et al. Antimicrob Agents Chemother. 2023 Sep 20:e0081823.
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