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Chemical Structure : ATN-161 TFA salt
CAS No.: 904763-27-5
Catalog No.: PC-21536Not For Human Use, Lab Use Only.
ATN-161 TFA salt (Ac-PHSCN-NH2) is a small peptide inhibitor of integrin alpha5 beta1 (α5β1) and alphavbeta3 (αvβ3) with binding Kd of 1.0 and 0.6 uM, respectively, inhibits breast cancer growth and metastasis.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
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ATN-161 TFA salt (Ac-PHSCN-NH2) is a small peptide inhibitor of integrin alpha5 beta1 (α5β1) and alphavbeta3 (αvβ3) with binding Kd of 1.0 and 0.6 uM, respectively, inhibits breast cancer growth and metastasis.
ATN-161 forms a disulfide bond with its integrin target.
ATN-161 (20 uM) significantly inhibits MAPK phosphorylation with maximal effects in MDA-MB-231 cells.
ATN-161 (1 mg/kg) inhibits MDA-MB-231 tumor growth in vivo, causes a significant dose-dependent decrease in tumor volume and either completely blocked or caused a marked decrease in the incidence and number of skeletal as well as soft tissue metastases.
| M.Wt | 712.66 | |
| Formula | C25H35F3N8O11S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
L-Aspartamide, 1-acetyl-L-prolyl-L-histidyl-L-seryl-L-cysteinyl-, mono(trifluoroacetate) (salt) |
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1. Cianfrocca ME, et al. Br J Cancer. 2006 Jun 5;94(11):1621-6.
2. Livant DL, et al. Cancer Res. 2000 Jan 15;60(2):309-20.
3. Khalili P, et al. Mol Cancer Ther. 2006 Sep;5(9):2271-80.
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