Chemical Structure : ATR-127
CAS No.:
2302006-36-4
ATR-127
(ATR127)
Catalog No.: PC-22446Not For Human Use, Lab Use Only.
ATR-127 is a highly effective β2- and β3-adrenoceptors (ARs) agonist with pEC50 of 6.53 and 5.5 for rat β2-AR and mouse β3-AR, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ATR-127 is a highly effective β2- and β3-adrenoceptors (ARs) agonist with pEC50 of 6.53 and 5.5 for rat β2-AR and mouse β3-AR, respectively.
ATR-127 is a full agonist but with a reduced potency compared to isoprenaline.
ATR-127 displayed weaker partial agonist activity compared to isoprenaline for rat β1-AR. exhibits differential cAMP generation capability and minimal desensitization response.
ATR-127 increases glucose uptake in skeletal muscle by stimulating β2-adrenoceptors.
ATR-127 induces glucose uptake and thermogenesis in brown adipocytes.
Chronic ATR-127 treatment improves glucose tolerance and body composition in DIO mice.
Physicochemical Properties
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M.Wt
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223.32
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Formula
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C13H21NO2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-((R)-1-hydroxy-2-(((R)-pentan-2-yl)amino)ethyl)phenol
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References
1. Emanuela Talamonti, et al. Mol Metab. 2024 May 17:101931.
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