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Chemical Structure : ATR-127
Catalog No.: PC-22446Not For Human Use, Lab Use Only.
ATR-127 is a highly effective β2- and β3-adrenoceptors (ARs) agonist with pEC50 of 6.53 and 5.5 for rat β2-AR and mouse β3-AR, respectively.
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ATR-127 is a highly effective β2- and β3-adrenoceptors (ARs) agonist with pEC50 of 6.53 and 5.5 for rat β2-AR and mouse β3-AR, respectively.
ATR-127 is a full agonist but with a reduced potency compared to isoprenaline.
ATR-127 displayed weaker partial agonist activity compared to isoprenaline for rat β1-AR. exhibits differential cAMP generation capability and minimal desensitization response.
ATR-127 increases glucose uptake in skeletal muscle by stimulating β2-adrenoceptors.
ATR-127 induces glucose uptake and thermogenesis in brown adipocytes.
Chronic ATR-127 treatment improves glucose tolerance and body composition in DIO mice.
| M.Wt | 223.32 | |
| Formula | C13H21NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Emanuela Talamonti, et al. Mol Metab. 2024 May 17:101931.
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