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AUNP-12

Chemical Structure : AUNP-12

CAS No.: 1353563-85-5

AUNP-12 (Aurigene-012, AUR 012, NP-12)

Catalog No.: PC-35694Not For Human Use, Lab Use Only.

AUNP-12 (Aurigene-012) is a PD-1 inhibitor peptide, blocks the PD-1/PD-L1, PD-1/PD-L2 and PD-L1/CD80 pathways.

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5 mg $238 In stock
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25 mg $578 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AUNP-12 (Aurigene-012) is a PD-1 inhibitor peptide, blocks the PD-1/PD-L1, PD-1/PD-L2 and PD-L1/CD80 pathways.
AUNP-12 is highly effective in antagonizing PD-1 signaling, with desirable in vivo exposure upon subcutaneous dosing.
AUNP-12 inhibits tumor growth and metastasis in preclinical models of cancer and is well tolerated with no overt toxicity at any of the tested doses.

Physicochemical Properties

M.Wt 3261.55
Formula 3261.6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N2,N6-bis(L-seryl-L-asparaginyl-L-threonyl-L-seryl-L-α-glutamyl-L-seryl-L-phenylalanyl)-L-lysyl-L-phenylalanyl-L-arginyl-L-valyl-L-threonyl-L-glutaminyl-L-leucyl-L-alanyl-L-prolyl-L-lysyl-L-alanyl-L-glutaminyl-L-isoleucyl-L-lysyl-L-α-glutamine

References

1. Gao, Y.; Chen, Y.; Qi, Y.; Liu, B. PD-L1 Affinity Peptide with Anti-Tumour Activity and Application Thereof. CN103304638A, 2013.

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