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AUT00201

Chemical Structure : AUT00201

CAS No.: 1380696-68-3

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AUT00201 (AUT 00201, AUT-00201)

Catalog No.: PC-21564Not For Human Use, Lab Use Only.

AUT00201 is a potent, selective Kv3 potassium channels positive allosteric modulator (PAM), increases the Kv3.1, Kv3.2 and Kv3.4 currents measured at -15mV in a concentration-dependent manner with pEC50 values of 6.15, 6.52, and 5.6, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AUT00201 is a potent, selective Kv3 potassium channels positive allosteric modulator (PAM), increases the Kv3.1, Kv3.2 and Kv3.4 currents measured at -15mV in a concentration-dependent manner with pEC50 values of 6.15, 6.52, and 5.6, respectively.
    AUT00201 also modulates human Kv3.2 and Kv3.4 channels with different potencies.
    AUT00201 (5 and 20 mg/kg) attenuates motor dysfunction, motor neuron loss and muscle pathology in SOD1-G93A mice.
    AUT00201 improves the phenotype of amyotrophic lateral sclerosis (ALS) mice specifically.

    Physicochemical Properties

    M.Wt 380.40
    Formula C20H20N4O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-5-ethyl-3-(2-((7-methyl-2H-spiro[benzofuran-3,1'-cyclopropan]-4-yl)oxy)pyrimidin-5-yl)imidazolidine-2,4-dione

    References

    1. Patent WO2012076877 A1.

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