AUT5

Chemical Structure : AUT5

Catalog No.: PC-27689Not For Human Use, Lab Use Only.

AUT5 is a highly selective positive allosteric modulator of Kv3.1 and Kv3.2 channels, induces positive cooperativity and preferential stabilization of the open state with EC50 of 3.2 uM (Kv3.2).

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Biological Activity

AUT5 is a highly selective positive allosteric modulator of Kv3.1 and Kv3.2 channels, induces positive cooperativity and preferential stabilization of the open state with EC50 of 3.2 uM (Kv3.2).

Physicochemical Properties

M.Wt	365.39
Formula	C20H19N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-(6-((2H-spiro[benzofuran-3,1'-cyclopropan]-4-yl)oxy)pyridin-3-yl)-5-ethylimidazolidine-2,4-dione

References

1. Liang Q, et al. Nat Commun. 2024 Mar 21;15(1):2533.

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AUT5

Biological Activity

Physicochemical Properties

References

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