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Chemical Structure : AUTEN-67
CAS No.: 1783800-77-0
Catalog No.: PC-60217Not For Human Use, Lab Use Only.
AUTEN-67 is a small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $588 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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AUTEN-67 is a small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14.
At concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively.
AUTEN-67 shows no activity for CDC25B , other phosphatase, PTPN1.
AUTEN-67 significantly increases autophagic flux in cell lines and in vivo models, promotes longevity and protects neurons from undergoing stress-induced cell death.
AUTEN-67 also restores nesting behavior in a murine model of Alzheimer disease, without apparent side effects.
| M.Wt | 474.45 | |
| Formula | C23H14N4O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(3-(1H-benzo[d]imidazol-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-nitrobenzenesulfonamide |
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1. Papp D, et al. Autophagy. 2016;12(2):273-86.
2. Billes V, et al. J Huntingtons Dis. 2016 May 7;5(2):133-47.
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