AUTEN-67 is a small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14.
At concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively.
AUTEN-67 shows no activity for CDC25B , other phosphatase, PTPN1.
AUTEN-67 significantly increases autophagic flux in cell lines and in vivo models, promotes longevity and protects neurons from undergoing stress-induced cell death.
AUTEN-67 also restores nesting behavior in a murine model of Alzheimer disease, without apparent side effects.
