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AUTEN-99

Chemical Structure : AUTEN-99

CAS No.: 904054-02-0

AUTEN-99 (AUTEN99)

Catalog No.: PC-70067Not For Human Use, Lab Use Only.

AUTEN-99 is a small molecule autophagy enhancer that inhibit the myotubularin-related phosphatase MTMR14/Jumpy.

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    Biological Activity

    AUTEN-99 is a small molecule autophagy enhancer that inhibit the myotubularin-related phosphatase MTMR14/Jumpy.
    AUTEN-99 induces autophagic flux and promotes cell survival in mammalian cell cultures.
    AUTEN-99 increases the number of autophagic structures in mice and Drosophila, and effectively penetrates through a blood-brain barrier model; impedes the progression of neurodegenerative symptoms in Drosophila models of Parkinson's and Huntington's diseases.

    Physicochemical Properties

    M.Wt 278.373
    Formula C17H14N2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-([1,1'-biphenyl]-4-yl)-5,6-dihydroimidazo[2,1-b]thiazole

    References

    1. Kovács T, et al. Sci Rep. 2017 Feb 16;7:42014.

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