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AUTEN-99 hydrobromide

Chemical Structure : AUTEN-99 hydrobromide

CAS No.: 1049780-58-6

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AUTEN-99 hydrobromide (AUTEN99 hydrobromide)

Catalog No.: PC-70066Not For Human Use, Lab Use Only.

A small molecule autophagy enhancer that inhibit the myotubularin-related phosphatase MTMR14/Jumpy.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AUTEN-99 hydrobromide is a small molecule autophagy enhancer that inhibit the myotubularin-related phosphatase MTMR14/Jumpy.
    AUTEN-99 induces autophagic flux and promotes cell survival in mammalian cell cultures.
    AUTEN-99 increases the number of autophagic structures in mice and Drosophila, and effectively penetrates through a blood-brain barrier model; impedes the progression of neurodegenerative symptoms in Drosophila models of Parkinson's and Huntington's diseases.

    Physicochemical Properties

    M.Wt 359.285
    Formula C17H15BrN2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-([1,1'-biphenyl]-4-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide

    References

    1. Kovács T, et al. Sci Rep. 2017 Feb 16;7:42014.

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