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Chemical Structure : AUZ454
CAS No.: 853299-07-7
Catalog No.: PC-35270Not For Human Use, Lab Use Only.
AUZ454 (AUZ-454, K03861) is a potent and selective, second-generation inhibitor of mutant FLT3 protein kinase.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | $588 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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AUZ454 (AUZ-454, K03861) is a potent and selective, second-generation inhibitor of mutant FLT3 protein kinase.
AUZ454 (AUZ-454, K03861) selectively kills leukemic cells harboring mutant FLT3 with no apparent effect on cells harboring wild-type FLT3, via inhibition of FLT3 kinase activity.
AUZ454 (AUZ-454, K03861) potently inhibits cell proliferation of FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells (IC50<1 nM), via induction of apoptosis.
| M.Wt | 501.514 | |
| Formula | C24H26F3N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(4-((2-aminopyrimidin-4-yl)oxy)phenyl)-3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)urea |
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1. Weisberg E, et al. Genes Cancer. 2010 Oct;1(10):1021-32.
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