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Chemical Structure : AVE-0118
CAS No.: 498577-53-0
Catalog No.: PC-62817Not For Human Use, Lab Use Only.
AVE-0118 is a potent I(to)/I(Kur) blocker, Kv1.5 channel inhibitor with IC50 of 5.6 uM, also blocks Kv1.3, Kv2.1, Kv3.1, and Kv4.3 channels with similar potency.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $438 | In stock | |
| 100 mg | Get quote |
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AVE-0118 is a potent I(to)/I(Kur) blocker, Kv1.5 channel inhibitor with IC50 of 5.6 uM, also blocks Kv1.3, Kv2.1, Kv3.1, and Kv4.3 channels with similar potency.
AVE-0118 dose-dependently prolongs the atrial refractoriness independent from rate and inhibits left atrial vulnerability (LAV) in vivo.
AVE-0118 fully restored atrial contraction without proarrhythmic effects on the ventricle.
| M.Wt | 479.58 | |
| Formula | C30H29N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2'-[[2-(4-Methoxyphenyl)acetylamino]methyl]biphenyl-2-carboxylic acid (2-pyridin-3-yl-ethyl)amide |
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1. de Haan S, et al. Circulation. 2006 Sep 19;114(12):1234-42.
2. Decher N, et al. Mol Pharmacol. 2006 Oct;70(4):1204-11.
3. Wettwer E, et al. Circulation. 2004 Oct 19;110(16):2299-306.
4. Wirth KJ, et al. Cardiovasc Res. 2003 Nov 1;60(2):298-306.
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