AVE-0118 | Kv1.5 inhibitor | Probechem Biochemicals

Chemical Structure : AVE-0118

CAS No.: 498577-53-0

AVE-0118 (AVE0118)

Catalog No.: PC-62817Not For Human Use, Lab Use Only.

AVE-0118 is a potent I(to)/I(Kur) blocker, Kv1.5 channel inhibitor with IC50 of 5.6 uM, also blocks Kv1.3, Kv2.1, Kv3.1, and Kv4.3 channels with similar potency.

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10 mg	$148	In stock
25 mg	$258	In stock
50 mg	$438	In stock
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Biological Activity

AVE-0118 is a potent I(to)/I(Kur) blocker, Kv1.5 channel inhibitor with IC50 of 5.6 uM, also blocks Kv1.3, Kv2.1, Kv3.1, and Kv4.3 channels with similar potency.
AVE-0118 dose-dependently prolongs the atrial refractoriness independent from rate and inhibits left atrial vulnerability (LAV) in vivo.
AVE-0118 fully restored atrial contraction without proarrhythmic effects on the ventricle.

Physicochemical Properties

M.Wt	479.58
Formula	C30H29N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2'-[[2-(4-Methoxyphenyl)acetylamino]methyl]biphenyl-2-carboxylic acid (2-pyridin-3-yl-ethyl)amide

References

1. de Haan S, et al. Circulation. 2006 Sep 19;114(12):1234-42.

2. Decher N, et al. Mol Pharmacol. 2006 Oct;70(4):1204-11.

3. Wettwer E, et al. Circulation. 2004 Oct 19;110(16):2299-306.

4. Wirth KJ, et al. Cardiovasc Res. 2003 Nov 1;60(2):298-306.

AVE-0118 (AVE0118)

Biological Activity

Physicochemical Properties

References

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