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AVG-233

Chemical Structure : AVG-233

CAS No.: 2151937-80-1

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AVG-233 (AVG-233)

Catalog No.: PC-35776Not For Human Use, Lab Use Only.

AVG-233 (AVG233) is a potent, allosteric inhibitor of respiratory syncytial virus (RSV) RNA-dependent RNA polymerase (RdRp) complex, demonstrates nanomolar activity against both laboratory-adapted RSV strains and clinical RSV isolates (EC50=34-79 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AVG-233 (AVG233) is a potent, allosteric inhibitor of respiratory syncytial virus (RSV) RNA-dependent RNA polymerase (RdRp) complex, demonstrates nanomolar activity against both laboratory-adapted RSV strains and clinical RSV isolates (EC50=34-79 nM).
    AVG-233 exhibits 34% oral bioavailability and sustained high drug levels in the circulation after a single oral dose of 20 mg/kg.

    Physicochemical Properties

    M.Wt 487.944
    Formula C26H22ClN5O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-((6-chloropyridin-2-yl)methyl)-1-(4-methoxybenzyl)-4-methyl-2-(pyridin-2-yl)-1,2-dihydro-3H-pyrazolo[4,3-c]pyridine-3,6(5H)-dione

    References

    1. Cox RM, et al. J Biol Chem. 2018 Oct 26;293(43):16761-16777.

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