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Chemical Structure : AVL-292
CAS No.: 1202757-89-8
Catalog No.: PC-45401Not For Human Use, Lab Use Only.
AVL-292 (Spebrutinib, CC-292) is a highly selective, covalent Btk inhibitor with IC50 of <1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | $358 | In stock | |
| 250 mg | Get quote |
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AVL-292 (Spebrutinib, CC-292) is a highly selective, covalent Btk inhibitor with IC50 of <1 nM.
AVL-292 (Spebrutinib, CC-292) also less potently inhibits Yes, c-Src, Brk, Lyn, and Fyn with IC50s of 723 nM, 1.729 uM, 2.43 uM, 4.4 uM, and 7.15 uM, rspectively.
AVL-292 (Spebrutinib, CC-292) shows anti-inflammatory activity in the collagen-induced arthritis model of autoimmune disease.
AVL-292 (Spebrutinib, CC-292) also prevents NRG- and EGF-dependent growth factor-driven resistance to lapatinib in HER2(+) breast cancer cells.
| M.Wt | 423.4402 | |
| Formula | C22H22FN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 45 mg/mL |
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| Chemical Name/SMILES |
2-Propenamide, N-[3-[[5-fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]- |
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1. Evans EK, et al. J Pharmacol Exp Ther. 2013 Aug;346(2):219-28.
2. Eda H, et al. Leukemia. 2014 Sep;28(9):1892-901.
3. Wang X, et al. Mol Cancer Ther. 2016 Sep;15(9):2198-208.
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