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Chemical Structure : AVL-292 besylate
Catalog No.: PC-45402Not For Human Use, Lab Use Only.
AVL-292 besylate (Spebrutinib, CC-292) is a highly selective, covalent Btk inhibitor with IC50 of <1 nM.
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AVL-292 besylate (Spebrutinib, CC-292) is a highly selective, covalent Btk inhibitor with IC50 of <1 nM.
AVL-292 besylate (Spebrutinib, CC-292) also less potently inhibits Yes, c-Src, Brk, Lyn, and Fyn with IC50s of 723 nM, 1.729 uM, 2.43 uM, 4.4 uM, and 7.15 uM, rspectively.
AVL-292 besylate (Spebrutinib, CC-292) shows anti-inflammatory activity in the collagen-induced arthritis model of autoimmune disease.
AVL-292 besylate (Spebrutinib, CC-292) also prevents NRG- and EGF-dependent growth factor-driven resistance to lapatinib in HER2(+) breast cancer cells.
| M.Wt | 581.6152 | |
| Formula | C28H28FN5O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Evans EK, et al. J Pharmacol Exp Ther. 2013 Aug;346(2):219-28.
2. Eda H, et al. Leukemia. 2014 Sep;28(9):1892-901.
3. Wang X, et al. Mol Cancer Ther. 2016 Sep;15(9):2198-208.
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